Radiosynthesis and preliminary: In vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

MB Haskali; D Denoyer; PD Roselt; RJ Hicks; CA Hutton

Journal article

Radiosynthesis and preliminary: In vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

MB Haskali, D Denoyer, PD Roselt, RJ Hicks, CA Hutton

Medchemcomm | ROYAL SOC CHEMISTRY | Published : 2019

DOI: 10.1039/c9md00354a

Abstract

Duramycin derivatives incorporating an [18F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [18F]FP-digalacto-duramycin exhibited a low Logd, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo.

University of Melbourne Researchers

Mo Haskali Author

Peter Roselt Author

Craig Hutton Author

Related Projects (1)

Solid phase synthesis of side-chain cross-linked peptide oligomers

This research will provide a unique opportunity to investigate the biological pathways and causative factors leading to diseases such as Alz..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

We acknowledge award of a PhD scholarship by the CRC for Biomedical Imaging to M. H., and funding from ARC DP DP120101454. Professor Hicks is the recipient of a NHMRC Practitioner Fellowship (APP1108050).